| Onyx Venus Global LLC CA | Transportation & Warehousing | 0 | - | F |
| OnyxMP GrowthCo Inc. TX | Retail Trade | 1 | $160,000 | - |
| Oodle AI, Inc. CA | Professional & Technical Services | 1 | $200,000 | - |
| Ooma, Inc. CA | Professional & Technical Services | 4 | $200,000 | - |
| Oorvi Systems Inc TX | Professional & Technical Services | 1 | $85,000 | - |
| Oostburg Concrete Products WI | Construction | 0 | - | F |
| OOTB Minds, Inc. DC | Professional & Technical Services | 6 | $127,000 | - |
| Oour Lady of Bellefonte Hospital, L.L.C. KY | - | 0 | - | - |
| OP Labs PBC CA | Professional & Technical Services | 3 | $250,000 | - |
| OP Mobility TN | - | 0 | - | - |
| OPA Ortho PLLC WA | Healthcare & Social Assistance | 1 | $250,000 | - |
| Opal Camera, Inc. CA | - | 1 | $205,000 | - |
| Opal Soft, Inc. CA | Professional & Technical Services | 1 | $110,800 | - |
| Opal-Foods Cooperative, INC CO | Agriculture & Forestry | 0 | - | F |
| Opal-Rt CORPORATION MI | - | 1 | $84,531 | - |
| Opala Health, Inc. WA | Professional & Technical Services | 1 | $135,000 | - |
| Opaque Systems, Inc. CA | Information & Media | 1 | $160,000 | - |
| Oparc CA | - | 0 | - | - |
| OPC Arbre Farms, LLC MI | Manufacturing | 0 | - | F |
| Opel Systems MI | Professional & Technical Services | 3 | $82,368 | - |
| Opelousas General Health System LA | Healthcare & Social Assistance | 0 | - | C |
| Opelsoft LLC NJ | Professional & Technical Services | 5 | $114,452 | - |
| Open 4 Business Productions, LLC CA | - | 0 | - | - |
| Open Access Technology International, Inc. MN | Information & Media | 6 | $118,250 | - |
| Open Arms Child Development Center AK | Healthcare & Social Assistance | 1 | $54,000 | - |
| Open Avenues Foundation MA | Other Services | 2 | $60,497 | - |
| Open Avenues Foundation NY | Other Services | 140 | $103,210 | - |
| Open Door AZ | - | 0 | - | - |
| Open Door Center ND | Healthcare & Social Assistance | 0 | - | F |
| Open Door Community Health Centers CA | Healthcare & Social Assistance | 1 | $217,235 | - |
| Open Door Health Center MN | - | 1 | $178,534 | - |
| Open Door Legal CA | Professional & Technical Services | 2 | $93,426 | - |
| Open Gates Group IA | Management of Companies | 0 | - | F |
| Open IT Labs LLC NJ | Professional & Technical Services | 2 | $113,640 | - |
| Open Molecular Software Foundation CA | Professional & Technical Services | 1 | $63,000 | - |
| Open Nature INC. CA | Educational Services | 4 | $134,000 | - |
| Open Office INC OR | Professional & Technical Services | 2 | $160,000 | - |
| Open Philanthropy Project CA | Professional & Technical Services | 4 | $109,328 | - |
| Open Queue, LLC AZ | Professional & Technical Services | 2 | $117,257 | - |
| Open Range Beef NE | Manufacturing | 0 | - | A |
| Open Residency LLC NY | Professional & Technical Services | 1 | $62,400 | - |
| Open Road Logistics LLC MI | Transportation & Warehousing | 0 | - | F |
| Open Security Alliance, Inc. CA | Professional & Technical Services | 1 | $81,786 | - |
| Open Sky Education, Inc. WI | Educational Services | 0 | - | B |
| Open Society Institute NY | Other Services | 1 | $106,090 | - |
| Open Source Integrators, Inc. AZ | Information & Media | 2 | $132,854 | - |
| Open Space Labs, Inc. CA | Professional & Technical Services | 3 | $103,106 | - |
| Open Square LLC WA | - | 0 | - | - |
| Open Staffing Foundation CA | Information & Media | 1 | $165,000 | - |
| Open Systems International, Inc. MN | Professional & Technical Services | 12 | $129,487 | - |
