| Institute for Education, Research, and Scholarships (IFERS) CA | Educational Services | 5 | $106,642 | - |
| Institute for Intergovernmental Research, Inc. FL | - | 0 | - | - |
| Institute for Molecular Medicine CA | Professional & Technical Services | 1 | $138,000 | - |
| Institute for Musculoskeletal Advancement IL | Professional & Technical Services | 4 | $85,592 | - |
| Institute for Palestine Studies - USA DC | Information & Media | 1 | $54,766 | - |
| Institute for Privacy-Preserving Marketing Analytics & Data Governance CO | - | 1 | $125,000 | - |
| Institute for Progress DC | - | 1 | $119,080 | - |
| Institute for Protein Innovation Inc. MA | - | 3 | $75,130 | - |
| Institute for Systems Biology WA | Professional & Technical Services | 4 | $73,965 | - |
| Institute for the International Education of Students IL | - | 0 | - | - |
| Institute for the Redesign of Learning CA | Educational Services | 0 | - | D |
| Institute for Therapy through the Arts IL | - | 1 | $59,000 | - |
| Institute for Women's Policy Research DC | - | 2 | $101,000 | - |
| Institute of Gas Technology IL | Professional & Technical Services | 9 | $118,000 | - |
| Institute of Information Technology, Inc. TX | Professional & Technical Services | 2 | $97,161 | - |
| Institute of International Finance DC | Other Services | 5 | $82,950 | - |
| Institute of Nuclear Medicine Inc. MD | Professional & Technical Services | 1 | $79,000 | - |
| Institute of Technology and Academics, Inc. WI | - | 1 | $55,000 | - |
| Institute on Aging CA | Healthcare & Social Assistance | 0 | - | F |
| Institutes of Applied Human Dynamics, Inc. NY | - | 0 | - | - |
| Institutional Capital Network, Inc. NY | Finance & Insurance | 24 | $130,000 | - |
| Institutional Shareholder Services Inc. MD | Finance & Insurance | 8 | $126,800 | - |
| Institutional Venture Management XIV, LLC CA | - | 1 | $106,000 | - |
| Instron, a Division of Illinois Tool Works MA | Manufacturing | 1 | $90,040 | - |
| Instructional ABA Consultants IL | Healthcare & Social Assistance | 1 | $78,607 | - |
| Instructional Coaching Group Inc. KS | - | 2 | $122,699 | - |
| Instructure, Inc. UT | - | 1 | $290,000 | - |
| Instrument LLC OR | Professional & Technical Services | 3 | $125,683 | - |
| Instrumental Services INC NY | Professional & Technical Services | 6 | $151,833 | - |
| Instrumental, Inc. CA | Professional & Technical Services | 6 | $142,220 | - |
| Instrumentation Laboratory (Werfen) NY | Manufacturing | 0 | - | D |
| Instrumentation Laboratory Company MA | Wholesale Trade | 5 | $128,734 | A |
| Insula Asset Management, LLC CA | - | 1 | $130,000 | - |
| Insulation Northwest, LLC WA | Construction | 0 | - | F |
| Insulet Corporation MA | Manufacturing | 31 | $159,757 | D |
| Insulsafe Textiles, Inc. ME | Manufacturing | 0 | - | C |
| Insurance Analytics Group, LLC OH | - | 1 | $125,000 | - |
| Insurance Auto Auctions, Inc. IL | Wholesale Trade | 10 | $148,234 | - |
| Insurance Auto Auctions, Inc. MD | - | 0 | - | - |
| Insurance Institute for Business & Home Safety SC | - | 1 | $136,637 | - |
| Insurance Leads.Com CA | - | 0 | - | - |
| Insurance Quantified, LLC DE | Professional & Technical Services | 2 | $170,888 | - |
| Insurance Services Office, Inc NJ | Finance & Insurance | 97 | $142,800 | - |
| Insurance.com OH | - | 0 | - | - |
| InsuredMine Inc. TX | Professional & Technical Services | 1 | $235,000 | - |
| Insurify, Inc. MA | Finance & Insurance | 1 | $112,500 | - |
| Insurity LLC CT | Professional & Technical Services | 9 | $147,126 | - |
| Insurtech, Inc. CA | Finance & Insurance | 1 | $210,000 | - |
| Insycom, Inc. MA | Professional & Technical Services | 4 | $97,971 | - |
| Insync Consulting Services LLC., CA | Administrative & Waste Services | 0 | - | F |
