| 2110 N Brown Rd Sugarloaf, LLC GA | Accommodation & Food Services | 0 | — | A |
| 212, LLC FL | Transportation & Warehousing | 0 | — | A |
| 2135 Manufacturing LLC NC | Manufacturing | 0 | — | A |
| 214 LCI ID | Manufacturing | 0 | — | F |
| 214 Laura Louise Lane LLC MT | Other Services | 0 | — | A |
| 2150 Management Co. VA | Construction | 0 | — | F |
| 216 CITY OF NASHVILLE - C080458 IL | Public Administration | 0 | — | D |
| 21615 Unitek Learning Education Group Corp. CA | — | 0 | — | — |
| 216W TX | Wholesale Trade | 0 | — | F |
| 2171 West Side Supermarket, Ltd. (Westside Market) NY | — | 0 | — | — |
| 219 Health Network, Inc. IN | Healthcare & Social Assistance | 1 | $220,000 | — |
| 21c Hotel MO | Accommodation & Food Services | 0 | — | A |
| 21c Hotels MO | Accommodation & Food Services | 0 | — | A |
| 21c Museum Hotel AR | Accommodation & Food Services | 0 | — | A |
| 21c Museum Hotel KY | Accommodation & Food Services | 0 | — | D |
| 21c Museum Hotel MO | — | 0 | — | — |
| 21c Museum Hotel NC | Accommodation & Food Services | 0 | — | A |
| 21c Museum Hotel OH | Accommodation & Food Services | 0 | — | A |
| 21C Museum Hotel OK | — | 0 | — | — |
| 21c Museum Hotel COVID19 NC | — | 0 | — | — |
| 21c Museum Hotel Lexington KY | — | 0 | — | — |
| 21c Museum Hotel Louisville - MGallery KY | — | 0 | — | — |
| 21c Museum Hotels Nashville TN | — | 0 | — | — |
| 21CT, Inc. TX | — | 0 | — | — |
| 21st Amendment Brewery Cafe CA | — | 0 | — | — |
| 21st Century Coop IA | Other Services | 0 | — | B |
| 21st Century Equipment, LLC CO | Wholesale Trade | 0 | — | B |
| 21st Century Equipment, LLC NE | Wholesale Trade | 0 | — | A |
| 21st Century Equipment, LLC WY | Wholesale Trade | 0 | — | F |
| 21st Century Home Health Services, Inc. CA | Healthcare & Social Assistance | 2 | $120,000 | — |
| 21st Century Mfg. SD | Manufacturing | 0 | — | A |
| 21st Century Parks Inc KY | Arts & Entertainment | 0 | — | F |
| 21st Century Plastics Corporation MI | Manufacturing | 0 | — | F |
| 21st Century Scientific, Inc. ID | Manufacturing | 0 | — | A |
| 22 East 54th Street Restaurant Corp dba Papillon Bistro and Bar NY | — | 0 | — | — |
| 22 What's Next, LLC PA | Other Services | 1 | $125,000 | — |
| 220 Laboratories CA | Manufacturing | 0 | — | C |
| 221 E Mountain CO | Construction | 0 | — | A |
| 2210 Santa Ana OPCO, LLC CA | Healthcare & Social Assistance | 0 | — | F |
| 221594831 PA | Manufacturing | 0 | — | F |
| 221655676 NJ | Administrative & Waste Services | 0 | — | B |
| 2240 Hinton Dr TX | Manufacturing | 0 | — | A |
| 225 Bennett Road Operating Company, LLC NY | Healthcare & Social Assistance | 0 | — | F |
| 225 Bennett Road Operating Company, LLC DBA Elderwood at Cheektowaga NY | Healthcare & Social Assistance | 0 | — | F |
| 227 LCI IN | Manufacturing | 0 | — | D |
| 228 LCI IN | Manufacturing | 0 | — | C |
| 228 GODFREY FIRE PROTECTION DISTRICT - C080115 IL | Public Administration | 0 | — | F |
| 228 West 10th Street, LLC dba L'Artusi NY | — | 0 | — | — |
| 228G LCI IN | Manufacturing | 0 | — | A |
| 229 Bennett Road Operating Company, LLC NY | Healthcare & Social Assistance | 0 | — | F |