| 2 Towns Ciderhouse OR | Manufacturing | 0 | - | F |
| 20 Times Rest LLC - 701 West, Lobby Bar, Paradise Club, and The Terrace and Outdoor Gardens NY | - | 0 | - | - |
| 20-20 Financial Consulting, INC. CO | Finance & Insurance | 1 | $110,000 | - |
| 20/20 Plumbing & Heating, inc CA | Construction | 0 | - | F |
| 20/20 Plumbing & Heating, Inc. NV | Construction | 0 | - | F |
| 200 Bassett Road Operating Company, LLC NY | Healthcare & Social Assistance | 0 | - | F |
| 200 STL Holdings, LLC d/b/a St. Louis Downtown Crowne Plaza Hotel MO | - | 0 | - | - |
| 201 Tanning & Spa NE | - | 0 | - | - |
| 2020 Companies TX | Retail Trade | 0 | - | A |
| 2024 Democratic National Convention Committee IL | - | 0 | - | - |
| 202548 - Epp - Tampa - Fl07 FL | Wholesale Trade | 0 | - | F |
| 203 LCI AL | Manufacturing | 0 | - | A |
| 20th Television CA | Information & Media | 0 | - | F |
| 21 Staff, LLC. CA | Professional & Technical Services | 12 | $104,565 | - |
| 210 the G, LLC NY | - | 0 | - | - |
| 211 West 34 Operating LLC (TGIF Restaurant) NY | - | 0 | - | - |
| 2150 Management Co. VA | Construction | 0 | - | F |
| 21615 Unitek Learning Education Group Corp. CA | - | 0 | - | - |
| 2171 West Side Supermarket, Ltd. (Westside Market) NY | - | 0 | - | - |
| 219 Health Network, Inc. IN | Healthcare & Social Assistance | 1 | $220,000 | - |
| 21c Museum Hotel MO | - | 0 | - | - |
| 21c Museum Hotel OH | Accommodation & Food Services | 0 | - | A |
| 21C Museum Hotel OK | - | 0 | - | - |
| 21c Museum Hotel COVID19 NC | - | 0 | - | - |
| 21c Museum Hotel Lexington KY | - | 0 | - | - |
| 21c Museum Hotel Louisville - MGallery KY | - | 0 | - | - |
| 21c Museum Hotels Nashville TN | - | 0 | - | - |
| 21CT, Inc. TX | - | 0 | - | - |
| 21st Amendment Brewery Cafe CA | - | 0 | - | - |
| 21st Century Equipment, LLC NE | Wholesale Trade | 0 | - | A |
| 21st Century Home Health Services, Inc. CA | Healthcare & Social Assistance | 5 | $125,000 | - |
| 21st Mortgage Corporation TN | - | 1 | $135,574 | - |
| 22 East 54th Street Restaurant Corp dba Papillon Bistro and Bar NY | - | 0 | - | - |
| 22 What's Next, LLC PA | Other Services | 1 | $125,000 | - |
| 220 Laboratories CA | Manufacturing | 0 | - | C |
| 2210 Santa Ana OPCO, LLC CA | Healthcare & Social Assistance | 0 | - | F |
| 227 LCI IN | Manufacturing | 0 | - | D |
| 228 West 10th Street, LLC dba L'Artusi NY | - | 0 | - | - |
| 22Miles, Inc. CA | Professional & Technical Services | 1 | $85,000 | - |
| 22nd Century Technologies, Inc. VA | Professional & Technical Services | 15 | $142,800 | - |
| 23 and Me CA | - | 0 | - | - |
| 23 Bottles of Beer, LLC CA | - | 0 | - | - |
| 2310 Broad Street LLC PA | - | 1 | $121,722 | - |
| 2355 Telegraph LLC, DBA Super Duper, CA | - | 0 | - | - |
| 2365 Mini Mart LLC GA | Retail Trade | 1 | $60,000 | - |
| 237 42nd Street Corp. NY | - | 0 | - | - |
| 23andMe, Inc. CA | Healthcare & Social Assistance | 5 | $171,151 | - |
| 24 Carrots CA | - | 0 | - | - |
| 24 Carrots Catering and Events CA | - | 0 | - | - |
| 24 East 12th Street Associates NY | - | 1 | $97,420 | - |