| Open Office INC OR | Professional & Technical Services | 1 | $160,000 | — |
| OPEN PACIFIC LOGISTICS, LLC CA | Transportation & Warehousing | 0 | — | A |
| Open Philanthropy Project CA | Professional & Technical Services | 4 | $109,328 | — |
| OPEN QUEUE, LLC AZ | Professional & Technical Services | 2 | $117,257 | — |
| Open Range Beef NE | Manufacturing | 0 | — | A |
| Open Residency LLC NY | Professional & Technical Services | 1 | $62,400 | — |
| OPEN ROAD LOGISTICS LLC MI | Transportation & Warehousing | 0 | — | F |
| Open Security Alliance, Inc. CA | Professional & Technical Services | 1 | $81,786 | — |
| Open Sky Education, Inc. WI | Educational Services | 0 | — | B |
| Open Society Institute NY | Other Services | 1 | $106,090 | — |
| Open Source Controls, LLC TN | Construction | 0 | — | A |
| Open Source Integrators, Inc. AZ | Information & Media | 2 | $132,854 | — |
| Open Space Labs, Inc. CA | Professional & Technical Services | 2 | $191,560 | — |
| Open Square LLC WA | — | 0 | — | — |
| Open Staffing Foundation CA | Information & Media | 1 | $165,000 | — |
| Open Systems Integrators, LLC NJ | Administrative & Waste Services | 0 | — | A |
| Open Systems International, Inc. MN | Professional & Technical Services | 6 | $113,826 | — |
| Open Systems Technologies DE, LLC MI | Professional & Technical Services | 1 | $55,000 | — |
| Open Systems Technologies, Inc. NY | Professional & Technical Services | 2 | $159,120 | — |
| OPEN SYSTEMS, INC. GA | Professional & Technical Services | 4 | $87,376 | — |
| Open Technology Fund DC | Other Services | 1 | $165,000 | — |
| Open Technology Solutions, LLC CO | Professional & Technical Services | 1 | $132,848 | — |
| Open Text Inc. MD | Information & Media | 5 | $145,041 | — |
| OpenAI OpCo, LLC CA | Professional & Technical Services | 48 | $341,385 | — |
| OpenAirInterface Foundation DE | Information & Media | 1 | $135,000 | — |
| OpenBox Solutions, Inc. MI | Professional & Technical Services | 4 | $111,437 | — |
| OpenClinica, LLC MA | Professional & Technical Services | 1 | $102,566 | — |
| OpenCloud IT Solutions Inc TX | Professional & Technical Services | 10 | $104,260 | — |
| Opendoor Labs Inc. AZ | Real Estate | 5 | $227,694 | — |
| Opendoor Labs Inc. CA | — | 0 | — | — |
| OPENEDGES SQUARE CORPORATION CA | Information & Media | 4 | $190,000 | — |
| OpenGov, Inc. CA | Information & Media | 2 | $123,406 | — |
| OpenGov, Inc. WI | Information & Media | 2 | $124,769 | — |
| Opening Ceremony, LLC (Broadway) NY | — | 0 | — | — |
| Opening Ceremony, LLC (Centre Street) NY | — | 0 | — | — |
| Opening Ceremony, LLC (Howard Street) NY | — | 0 | — | — |
| OpenKyber LLC TX | Professional & Technical Services | 4 | $85,192 | — |
| OPENLANE INC AZ | Management of Companies | 0 | — | A |
| OPENLANE, Inc. IN | Wholesale Trade | 1 | $102,000 | — |
| OpenLight Photonics, Inc. CA | Professional & Technical Services | 1 | $153,254 | — |
| Openlink Financial LLC NY | Professional & Technical Services | 1 | $135,000 | — |
| OpenLogix LLC MI | Professional & Technical Services | 10 | $107,710 | — |
| Openly LLC MA | Finance & Insurance | 2 | $110,687 | — |
| OPENMIND SOLUTIONS LLC. TX | Professional & Technical Services | 1 | $105,976 | — |
| OpenMinds Lab, Inc. CA | Professional & Technical Services | 1 | $86,000 | — |
| OPENOBSERVE INC. CA | Information & Media | 1 | $230,000 | — |
| OPENRXIV CORP. NY | Information & Media | 1 | $87,250 | — |
| Opensoft, Inc. GA | Professional & Technical Services | 1 | $109,429 | — |
| OpenTable, Inc. CA | Information & Media | 1 | $325,000 | — |
| OpenTable, Inc. CT | Administrative & Waste Services | 6 | $193,375 | — |
