| OP Labs PBC CA | Professional & Technical Services | 2 | $230,000 | — |
| OP Mobility TN | — | 0 | — | — |
| OP/TECH USA HOLDING MT | Manufacturing | 0 | — | A |
| OP/TECH USA, LLC MT | Manufacturing | 0 | — | D |
| OPA Ortho PLLC WA | Healthcare & Social Assistance | 1 | $250,000 | — |
| OPAL WI | Healthcare & Social Assistance | 0 | — | A |
| Opal Senior Living FL | Healthcare & Social Assistance | 0 | — | F |
| Opal Soft, Inc. CA | Professional & Technical Services | 1 | $110,800 | — |
| Opal-Foods MO | Agriculture & Forestry | 0 | — | C |
| Opal-Foods Cooperative, INC CO | Agriculture & Forestry | 0 | — | F |
| Opal-Foods Cooperative, INC IA | Agriculture & Forestry | 0 | — | D |
| Opal-Foods Cooperative, INC MO | Agriculture & Forestry | 0 | — | B |
| Opala Health, Inc. WA | Professional & Technical Services | 1 | $135,000 | — |
| Opaque Systems, Inc. CA | Information & Media | 1 | $160,000 | — |
| Oparc CA | — | 0 | — | — |
| OPC Arbre Farms, LLC MI | Manufacturing | 0 | — | F |
| OPC Contracting OH | Construction | 0 | — | A |
| OPC Corporate and Midstream, OOG Corporate, Oxy USA Inc. TX | Mining & Extraction | 0 | — | A |
| OPC Polymers LLC OH | Manufacturing | 0 | — | A |
| Opco Altoona Ia LLC IA | Healthcare & Social Assistance | 0 | — | F |
| Opco, Inc PA | Manufacturing | 0 | — | F |
| Opel Systems MI | Professional & Technical Services | 2 | $96,252 | — |
| Opelousas General Health System LA | Healthcare & Social Assistance | 0 | — | C |
| OPELSOFT LLC NJ | Professional & Technical Services | 1 | $126,090 | — |
| Open 4 Business Productions, LLC CA | — | 0 | — | — |
| Open Access Technology International, Inc. MN | Information & Media | 4 | $143,107 | — |
| Open Arms Child Development Center AK | Healthcare & Social Assistance | 1 | $54,000 | — |
| Open Arms Health Systems OH | Healthcare & Social Assistance | 0 | — | F |
| Open Arms Home Health Care - Council Bluffs LLC IA | Healthcare & Social Assistance | 0 | — | F |
| Open Arms Home Health Care - Des Moines LLC IA | Healthcare & Social Assistance | 0 | — | F |
| Open Arms Home Health Care - Waterloo LLC IA | Healthcare & Social Assistance | 0 | — | F |
| Open Arms Home Health Care LLC IA | Healthcare & Social Assistance | 0 | — | A |
| Open Avenues Foundation MA | Other Services | 2 | $60,497 | — |
| Open Avenues Foundation NY | Other Services | 84 | $83,819 | — |
| Open Cities Health Center MN | Healthcare & Social Assistance | 0 | — | D |
| Open Door AZ | — | 0 | — | — |
| Open Door Center ND | Healthcare & Social Assistance | 0 | — | F |
| Open Door Community Health Centers CA | Healthcare & Social Assistance | 1 | $217,235 | — |
| Open Door Legal CA | Professional & Technical Services | 2 | $93,426 | — |
| Open Door Packaging, LLC. CA | Transportation & Warehousing | 0 | — | A |
| Open Door Rehabilitation Center IL | Healthcare & Social Assistance | 0 | — | D |
| Open Gates Group IA | Management of Companies | 0 | — | F |
| Open Grounds Farm, Inc. NC | Agriculture & Forestry | 0 | — | D |
| Open Harvest Co-op Grocery NE | Retail Trade | 0 | — | A |
| Open IT Labs LLC NJ | Professional & Technical Services | 2 | $113,640 | — |
| Open Loop Energy, Inc. AZ | Manufacturing | 0 | — | D |
| Open Loop Energy, Inc. NM | Manufacturing | 0 | — | F |
| Open Loop Energy, Inc. NV | Manufacturing | 0 | — | A |
| Open Molecular Software Foundation CA | Professional & Technical Services | 1 | $63,000 | — |
| OPEN NATURE INC. CA | Educational Services | 1 | $103,522 | — |
