| Upstate Systems, Inc. NY | Wholesale Trade | 0 | — | A |
| UpStream Care Company NC | — | 0 | — | — |
| Upstream Vision LLC TN | Professional & Technical Services | 1 | $83,464 | — |
| UPTICK SOFTWARE US INC CA | Information & Media | 1 | $137,000 | — |
| Uptik Solutions Inc TX | Professional & Technical Services | 2 | $127,878 | — |
| Uptime Cooling Systems NJ | Other Services | 0 | — | A |
| UpTime Electric Company Inc. GA | Construction | 0 | — | A |
| UPTIQ INC. TX | Information & Media | 3 | $812,400 | — |
| Upton's Naturals IL | Manufacturing | 0 | — | A |
| Uptons Inc DBA School Foodies CA | Accommodation & Food Services | 0 | — | F |
| Uptown Airport Group LLC NC | — | 0 | — | — |
| Uptown Bake & Brew LLC MD | Manufacturing | 0 | — | F |
| Uptown Care & Rehab Center IL | Healthcare & Social Assistance | 0 | — | F |
| Uptown Chevrolet-Cadillac, Inc. NY | — | 0 | — | — |
| Uptown Collab MN | — | 0 | — | — |
| Uptown Healthcare Center CO | Healthcare & Social Assistance | 0 | — | F |
| Uptown Industries WY | Administrative & Waste Services | 0 | — | A |
| Uptown Productions, Inc. - Burbank Studios CA | — | 0 | — | — |
| Uptown Productions, Inc. - Paramount Lot CA | — | 0 | — | — |
| Uptown Rental Properties LLC OH | Real Estate | 0 | — | B |
| Uptown VFW MN | — | 0 | — | — |
| Uptown Westerville Healthcare OH | — | 0 | — | — |
| UPTREND TECHNOLOGIES LLC MD | Professional & Technical Services | 9 | $92,754 | — |
| Upturn Business Inc. CA | — | 0 | — | — |
| Uptycs, Inc. MA | Professional & Technical Services | 1 | $108,200 | — |
| UPU Industries, Inc. KS | Manufacturing | 0 | — | F |
| Upward Enterprises NY | Agriculture & Forestry | 0 | — | A |
| Upward Innovations LLC TX | Professional & Technical Services | 4 | $86,664 | — |
| Upward Logistics Group LLC TX | Transportation & Warehousing | 0 | — | F |
| Upward Partners, LLC., dba Resale.com UT | Retail Trade | 0 | — | B |
| Upward Systems Inc TX | Professional & Technical Services | 1 | $80,746 | — |
| Upway USA, Inc NY | Other Services | 1 | $169,600 | — |
| UpWest MN | — | 0 | — | — |
| Upwind Security, Inc. CA | Information & Media | 1 | $230,000 | — |
| Upwing Energy, Inc. CA | Professional & Technical Services | 2 | $122,500 | — |
| Upwork Global LLC CA | Professional & Technical Services | 11 | $1,361,190 | — |
| Upwork, Inc. CA | Professional & Technical Services | 10 | $220,714 | — |
| Upwork, Inc. IL | — | 0 | — | — |
| UR International, Inc. TX | Professional & Technical Services | 3 | $107,333 | — |
| UR Medicine Thompson Health NY | Healthcare & Social Assistance | 0 | — | F |
| UR TECHNOLOGIES INC MN | Professional & Technical Services | 2 | $96,803 | — |
| Urartu Logistics Inc PA | Transportation & Warehousing | 0 | — | C |
| Urata & Sons Concrete, LLC CA | Construction | 0 | — | F |
| Urbahn Architects PLLC NY | Professional & Technical Services | 2 | $77,126 | — |
| Urban Air CT | Arts & Entertainment | 0 | — | A |
| Urban Air Adventure Park NJ | Arts & Entertainment | 0 | — | D |
| Urban Air Adventure Park NY | Arts & Entertainment | 0 | — | A |
| Urban Air Noblesville LLC IN | Arts & Entertainment | 0 | — | A |
| Urban Air Robinson LLC PA | Arts & Entertainment | 0 | — | F |
| Urban Alchemy CA | Other Services | 0 | — | F |
